DelveInsight’s “Wet-AMD Pipeline Insight 2026” report provides comprehensive insights about 60+ companies and 75+ pipeline drugs in the Wet-AMD pipeline landscape. It covers the Wet-AMD Pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Wet-AMD Pipeline Therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Curious about the latest updates in the Wet-AMD Pipeline? @ https://www.delveinsight.com/sample-request/wet-age-related-macular-degeneration-wet-amd-pipeline-insight

Key Takeaways from the Wet-AMD Pipeline Report

• On July 06, 2026- EyePoint Pharmaceuticals Inc. initiated a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
• On June 23, 2026- Genentech Inc. conducted a phase I/II study aims to evaluate the ocular and systemic safety, tolerability and efficacy of RO7446603 in participants with diabetic macular edema (DME). The study consists of 2 segments: Phase I (Parts 1-4) and Phase II (Part 5). Phase I investigated the safety of RO7446603 following a single and multiple intravitreal (IVT) doses as monotherapy or co-administered with IVT aflibercept or IVT faricimab (in separate injections).
• On June 23, 2026- Boehringer Ingelheim announced a phase I/IIa study is open to adults with diabetic macular edema that involves the center of the eye. The purpose of this study is to find out how well different doses of a medicine called BI 3812465 are tolerated by people with this condition. This is the first time BI 3812465 is given to humans.
• DelveInsight’s Wet-AMD Pipeline report depicts a robust space with 60+ active players working to develop 75+ pipeline therapies for Wet-AMD treatment.
• The leading Wet-AMD Companies such as Sylentis, Molecular Partners, Sam Chun Dang Pharm, Generium, Alvotech, Adverum Biotechnologies, EyePoint Pharmaceuticals, 4D Molecular Therapeutics, OliX Pharmaceuticals, Kyowa Kirin, Exonate and others.
• Promising Wet-AMD Therapies such as NT-101 0.05 mM, AVT06, RGX-314, ABP 938, Aflibercept, HX9428 tablet, FT-003, Ranibizumab, Tarcocimab Tedromer, LFG316 and others.

Want to know which companies are leading innovation in Wet-AMD? Dive into the full pipeline insights @ Wet-AMD Clinical Trials Assessment

The Wet-AMD Pipeline Report provides disease overview, pipeline scenario and therapeutic assessment of the key pipeline therapies in this domain. The Wet-AMD Pipeline Report also highlights the unmet needs with respect to the Wet-AMD.

Wet-AMD Overview

Wet Age-related Macular Degeneration (AMD) is a chronic eye disease that affects the macula, the central part of the retina responsible for sharp, detailed vision. It is a more severe form of AMD compared to the dry type and progresses rapidly, leading to significant vision loss if untreated. Wet AMD occurs when abnormal blood vessels grow under the macula, leaking blood or fluid, which disrupts retinal function and causes scarring. This condition primarily affects older adults, usually over the age of 50, and is a leading cause of central vision loss in this age group.

Wet-AMD Emerging Drugs Profile

• RGX-314: REGENXBIO

RGX-314 is a one-time subretinal treatment that includes the NAV AAV8 vector containing a gene encoding for a monoclonal antibody fragment. The expressed protein is designed to neutralize vascular endothelial growth factor (VEGF) activity, modifying the pathway for the formation of new leaky blood vessels and retinal fluid accumulation. RGX-314 is being developed as a potentially one-time treatment for wet AMD, diabetic retinopathy, and other additional chronic retinal conditions treated with anti-VEGF. REGENXBIO is advancing research in two separate routes of administration of RGX-314 to the eye, through a standardized subretinal delivery procedure as well as delivery to the suprachoroidal space. Currently, the drug is in the Phase III stage of its development for the treatment of Wet Age-Related Macular Degeneration (AMD).

• CLS-AX: Clearside Biomedical

CLS‑AX is a proprietary axitinib injectable suspension delivered via Clearside’s suprachoroidal space (SCS) Microinjector®, designed as a long-acting treatment for wet age-related macular degeneration (wet AMD). It’s a potent, pan‑VEGF tyrosine kinase inhibitor (TKI) that offers targeted, durable delivery behind the retina, potentially reducing injection frequency while maintaining stable visual acuity. CLS‑AX has demonstrated positive safety and efficacy in Phase IIb (ODYSSEY) results and is currently being advanced toward a Phase III development program

• SYL1801: Sylentis

SYL1801 is a small interfering RNA (siRNA) in the non-clinical research phase. This siRNA, by means of mechanism of action based on RNA interference (RNAi), inhibits the synthesis of NRARP (Notch-regulated ankyrin repeat-containing protein). NRARP is directly involved in the pathophysiology of choroidal neovascularization, i.e. the abnormal formation of new vessels from the choroid into the retina. It is a common hallmark of several retinal diseases such as age-related macular degeneration (AMD) or diabetic retinopathy (DR). During angiogenesis (new vessel formation), NRARP integrates the Notch and Wnt signaling pathways by controlling stalk cell proliferation to stabilize new endothelial cell connections . Currently the drug in in Phase II stage of its treatment of Wet Age-Related Macular Degeneration (Wet-AMD).

• IBI 333: Innovent Biologics

IBI‑333 is an investigational bispecific fusion protein developed by Innovent Biologics targeting both VEGF‑A and VEGF‑C. It’s currently in Phase I trials (for neovascular age‑related macular degeneration), where it is delivered via intravitreal injection to block dual angiogenic pathways and potentially overcome resistance seen with VEGF‑A monotherapy. Currently the drug in in Phase I stage of its treatment of Wet Age-Related Macular Degeneration (Wet-AMD).

If you’re tracking ongoing Wet-AMD Clinical trials, this press release is a must-read @ Wet-AMD Treatment Drugs

The Wet-AMD Pipeline report provides insights into:-

• The report provides detailed insights about companies that are developing therapies for the treatment of Wet-AMD with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Wet-AMD Treatment.
• Wet-AMD Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Wet-AMD Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Wet-AMD market.

Wet-AMD Companies

Sylentis, Molecular Partners, Sam Chun Dang Pharm, Generium, Alvotech, Adverum Biotechnologies, EyePoint Pharmaceuticals, 4D Molecular Therapeutics, OliX Pharmaceuticals, Kyowa Kirin, Exonate and others.

Wet-AMD Pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as,

• Intravenous
• Subcutaneous
• Oral
• Intramuscular

Wet-AMD Products have been categorized under various Molecule types such as,

• Monoclonal antibody
• Small molecule
• Peptide

From emerging drug candidates to competitive intelligence, the Wet-AMD Pipeline Report covers it all @ Wet-AMD Market Drivers and Barriers, and Future Perspectives

Scope of the Wet-AMD Pipeline Report

• Coverage- Global
• Wet-AMD Companies- Sylentis, Molecular Partners, Sam Chun Dang Pharm, Generium, Alvotech, Adverum Biotechnologies, EyePoint Pharmaceuticals, 4D Molecular Therapeutics, OliX Pharmaceuticals, Kyowa Kirin, Exonate and others.
• Wet-AMD Therapies- NT-101 0.05 mM, AVT06, RGX-314, ABP 938, Aflibercept, HX9428 tablet, FT-003, Ranibizumab, Tarcocimab Tedromer, LFG316 and others.
• Wet-AMD Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Wet-AMD Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

Discover what’s next for the Wet-AMD Treatment landscape in this detailed analysis @ Wet-AMD Emerging Drugs and Major Players

Table of Contents

1. Introduction
2. Executive Summary
3. Wet Age-Related Macular Degeneration: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Wet Age-Related Macular Degeneration (Wet-AMD)– DelveInsight’s Analytical Perspective
7. Late Stage Products (Phase III)
8. RGX-314: REGENXBIO
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. SYL1801: Sylentis
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. IBI 333: Innovent Biologics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug Name: Company Name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Wet Age-Related Macular Degeneration (Wet-AMD) Key Companies
21. Wet Age-Related Macular Degeneration (Wet-AMD) Key Products
22. Wet Age-Related Macular Degeneration (Wet-AMD)- Unmet Needs
23. Wet Age-Related Macular Degeneration (Wet-AMD)- Market Drivers and Barriers
24. Wet Age-Related Macular Degeneration (Wet-AMD)- Future Perspectives and Conclusion
25. Wet Age-Related Macular Degeneration (Wet-AMD) Analyst Views
26. Wet Age-Related Macular Degeneration (Wet-AMD) Key Companies
27. Appendix

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