DelveInsight’s, “Pulmonary Fibrosis Pipeline Insight 2026” report provides comprehensive insights about 110+ companies and 140+ pipeline drugs in Pulmonary Fibrosis pipeline landscape. It covers the Pulmonary Fibrosis Pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Pulmonary Fibrosis Pipeline Therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Pulmonary Fibrosis Pipeline Report

• On June 23, 2026- Contineum Therapeutics announced a phase 2 study to evaluate the efficacy, safety, tolerability, and PK of PIPE-791 in subjects with a diagnosis of Idiopathic Pulmonary Fibrosis with or without background treatment. The treatment period is 26 weeks and full study duration is up to 36 weeks including Screening and Follow-Up.
• On June 12, 2026- Mediar Therapeutics conducted a phase 2a study of the Safety and Efficacy of MTX-463 in Participants with Idiopathic Pulmonary Fibrosis (IPF).
• On June 11, 2026- Boehringer Ingelheim initiated a study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550. The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need to go to the hospital, or die.
• On June 05, 2026- Rein Therapeutics conducted a research is to evaluate LTI-03 including: its safety, whether it causes side effects, whether it improves lung scarring, and whether it improves IPF symptoms. LTI-03 will be compared to placebo in patients diagnosed with IPF within the last 5 years. Patients on a stable dose of nintedanib, pirfenidone, or nerandomilast (if available by prescription) may participate.
• DelveInsight’s Pulmonary Fibrosis Pipeline report depicts a robust space with 110+ active players working to develop 140+ pipeline therapies for Pulmonary Fibrosis treatment.
• The leading Pulmonary Fibrosis Companies such as Bristol-Myers Squibb, PureTech Health, Sarepta Therapeutics, Boehringer Ingelheim, Avalyn Pharma, SRN-001, Wuhan Optics Valley Vcanbiopharma Co., Ltd., Syndax Pharmaceuticals, Endeavor BioMedicines, AstraZeneca, Pulmongene Ltd., Agomab Therapeutics and others.
• Promising Pulmonary Fibrosis Pipeline Therapies such as BMS-986278, Pirfenidone, Etanercept, BI 1839100, CNTO 888 1 mg/kg, Nintedanib, Pirfenidoneone and others.

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The Pulmonary Fibrosis Pipeline Report provides disease overview, pipeline scenario and therapeutic assessment of the key pipeline therapies in this domain. The Pulmonary Fibrosis Pipeline Report also highlights the unmet needs with respect to the Pulmonary Fibrosis.

Pulmonary Fibrosis Overview

Pulmonary fibrosis is a chronic and progressive lung disease characterized by the excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. This leads to scarring and thickening of the lung tissue, which impairs gas exchange and results in a gradual decline in respiratory function. The disease is clinically recognizable by symptoms such as shortness of breath, chronic cough, and fatigue, with radiographic imaging revealing characteristic patterns of interstitial fibrosis.

Pulmonary Fibrosis Emerging Drugs Profile

• BMS-986278: Bristol-Myers Squibb

BMS-986278 is a potential first-in-class, oral, small molecule lysophosphatidic acid receptor 1 (LPA1) antagonist currently being evaluated as a novel antifibrotic treatment for patients with idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. Increased LPA levels and activation of LPA are involved in the pathogenesis of pulmonary fibrosis. BMS-986278 is a potent and complete antagonist of LPA action at LPA1-mediated Gi, Gq, G12, and β-arrestin signaling pathways in both cells heterologously expressing human LPA1 and in primary human lung fibroblasts. The drug is currently in Phase III stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

• AK3280: Ark Biosciences Inc.

AK3280 is a next-generation broad-spectrum anti-fibrotic molecule optimized from the marketed drug pirfenidone. It has the ability to modulate multiple pathways and biomarkers closely associated with the fibrotic process, including the expression of fibrosis-related genes and proteins induced by transforming growth factor-beta (TGF-B) and lysophosphatidic acid (LPA). AK3280 works by reducing cell proliferation and inhibiting the synthesis and accumulation of extracellular matrix. Compared to pirfenidone, AK3280 offers advantages in safety and tolerability, with potentially much better clinical efficacy. The drug is currently in Phase II stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

• LYT-100: PureTech Health

LYT-100 (deupirfenidone) is currently in development for idiopathic pulmonary fibrosis (IPF), which is a rare, progressive and fatal disease. LYT-100 is a deuterated form of pirfenidone and is designed to retain the beneficial pharmacology and clinically-validated efficacy of pirfenidone with a highly differentiated pharmacokinetic (PK) profile. In multiple clinical trials, LYT-100 has demonstrated a favorable tolerability profile, which may keep patients on treatment longer to enable more optimal disease management. The drug is currently in Phase II stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

• ARO-MMP7: Sarepta Therapeutics

ARO-MMP7 is an investigational RNA interference (RNAi) therapeutic developed by Arrowhead Pharmaceuticals, aimed at treating idiopathic pulmonary fibrosis (IPF) by targeting and reducing the expression of matrix metalloproteinase 7 (MMP7). This protein is implicated in the pathogenesis of IPF, contributing to inflammation and fibrosis in the lungs. The drug is currently in Phase I/II stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

• TRK-250: Toray Industries, Inc

TRK-250, also known as BNC-1021, is a nucleic acid medicine developed by Toray Industries in collaboration with BONAC Corporation. It is designed to treat Idiopathic Pulmonary Fibrosis (IPF). The drug works by selectively inhibiting the expression of transforming growth factor-beta 1 (TGF-β1), a key protein involved in the fibrotic process at the gene expression level. The drug is currently in Phase I stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

• VUM02: Wuhan Optics Valley Vcanbiopharma Co., Ltd.

VUM02 Injection is an innovative therapeutic product developed by Wuhan Optics Valley Vcanbiopharma Co., Ltd. It utilizes human umbilical cord-derived mesenchymal stem cells (hUCT-MSCs). The drug is currently in Phase I stage of clinical trial evaluation for the treatment of pulmonary fibrosis.

Explore groundbreaking therapies and clinical trials in the Pulmonary Fibrosis Pipeline @ New Pulmonary Fibrosis Drugs

The Pulmonary Fibrosis Pipeline Report Provides Insights into

• The report provides detailed insights about companies that are developing therapies for the treatment of Pulmonary Fibrosis with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Pulmonary Fibrosis Treatment.
• Pulmonary Fibrosis Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Pulmonary Fibrosis Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Pulmonary Fibrosis market

Pulmonary Fibrosis Companies

Bristol-Myers Squibb, PureTech Health, Sarepta Therapeutics, Boehringer Ingelheim, Avalyn Pharma, SRN-001, Wuhan Optics Valley Vcanbiopharma Co., Ltd., Syndax Pharmaceuticals, Endeavor BioMedicines, AstraZeneca, Pulmongene Ltd., Agomab Therapeutics and others.

Pulmonary Fibrosis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

Pulmonary Fibrosis Products have been categorized under various Molecule types such as

• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Learn about new drugs, pipeline developments, and key companies with DelveInsight’s expert analysis @ Pulmonary Fibrosis Market Drivers and Barriers

Scope of the Pulmonary Fibrosis Pipeline Report

• Coverage- Global
• Pulmonary Fibrosis Companies- Bristol-Myers Squibb, PureTech Health, Sarepta Therapeutics, Boehringer Ingelheim, Avalyn Pharma, SRN-001, Wuhan Optics Valley Vcanbiopharma Co., Ltd., Syndax Pharmaceuticals, Endeavor BioMedicines, AstraZeneca, Pulmongene Ltd., Agomab Therapeutics and others.
• Pulmonary Fibrosis Pipeline Therapies– BMS-986278, Pirfenidone, Etanercept, BI 1839100, CNTO 888 1 mg/kg, Nintedanib, Pirfenidoneone and others.
• Pulmonary Fibrosis Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Pulmonary Fibrosis Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content

1. Introduction
2. Executive Summary
3. Pulmonary Fibrosis: Overview
4. Therapeutic Assessment
5. Pulmonary Fibrosis– DelveInsight’s Analytical Perspective
6. Late Stage Products (Phase III)
7. BMS-986278: Bristol-Myers Squibb
8. Drug profiles in the detailed report…..
9. Mid Stage Products (Phase II)
10. AK3280: Ark Biosciences Inc.
11. Drug profiles in the detailed report…..
12. Early Stage Products (Phase I)
13. VUM02: Wuhan Optics Valley Vcanbiopharma Co., Ltd.
14. Drug profiles in the detailed report…..
15. Preclinical and Discovery Stage Products
16. RSBT 001: RS BioTherapeutics
17. Drug profiles in the detailed report…..
18. Inactive Products
19. Pulmonary Fibrosis Key Companies
20. Pulmonary Fibrosis Key Products
21. Pulmonary Fibrosis- Unmet Needs
22. Pulmonary Fibrosis- Market Drivers and Barriers
23. Pulmonary Fibrosis- Future Perspectives and Conclusion
24. Pulmonary Fibrosis Analyst Views
25. Pulmonary Fibrosis Key Companies
26. Appendix

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