DelveInsight’s, “Dry Age-Related Macular Degeneration Pipeline Insight 2023,” report provides comprehensive insights about 58+ companies and 64+ pipeline drugs in the Dry Age-Related Macular Degeneration pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
For Dry Age-Related Macular Degeneration Emerging drugs, the Dry Age-Related Macular Degeneration pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Dry Age-Related Macular Degeneration pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.
In the Dry Age-Related Macular Degeneration Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Dry Age-Related Macular Degeneration clinical trials studies, Dry Age-Related Macular Degeneration NDA approvals (if any), and product development activities comprising the technology, Dry Age-Related Macular Degeneration collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.
Key takeaways from the Dry Age-Related Macular Degeneration Pipeline Report
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Dry Age-Related Macular Degeneration Overview
Age-related macular degeneration (AMD) is a degenerative disease of the center area of the ocular-posterior segment (the macula lutea) that causes slow degeneration in central vision and severe disability in affected persons. “Age-related” means that it mainly occurs with elderly adults, while “Macular” means that the macula part of the eye is damaged. AMD mostly affects people aged above 50, and it was first reported more than 80 years ago.
Recent Developments Activities in the Dry Age- related Macular Degeneration Treatment Landscape
For further information, refer to the detailed Dry Age-Related Macular Degeneration Drugs Launch, Dry Age-Related Macular Degeneration Developmental Activities, and Dry Age-Related Macular Degeneration News, click here for Dry Age-Related Macular Degeneration Ongoing Clinical Trial Analysis
Dry Age-related Macular Degeneration Emerging Drugs Profile
ALK-001 is once-a-day oral drug candidate currently being tested for the treatment of geographic atrophy (advanced form of dry AMD) and Stargardt disease. Toxic vitamin A aggregates called “dimers” are known to rapidly form due to a genetic defect in Stargardt, or to accumulate with age in the case of dry AMD. These toxic dimers have been implicated in the degeneration of the retina seen in Stargardt and AMD. Dimers form when two molecules of vitamin A are chemically combined. ALK-001 is form of vitamin A that has been chemically-modified to prevent its aggregation into dimers.
Elamipretide (Stealth BioTherapeutics) is a novel tetrapeptide drug currently in development for both common and orphan diseases that involve dysfunction of the mitochondria, the cellular organelles that generates chemical energy in the form of adenosine triphosphate (ATP). At the cellular level, mitochondrial dysfunction causes loss of ATP production, increased levels of reactive oxygen species (eg, superoxide), calcium dysregulation, and, if prolonged, cell death. Elamipretide, given as systemic injection, penetrates tissues and cells and enters the mitochondria, where it reverses mitochondrial dysfunction (improved ATP production, restored mitochondrial membrane potential, normal calcium flux, and reduced superoxide generation).
Regenerative Patch Technologies has developed composite subretinal implant, termed the California Project to Cure Blindness-Retinal Pigment Epithelium 1 (CPCB-RPE1), consisting of a polarized monolayer of human embryonic stem cell-derived RPE (hESC-RPE) on an ultrathin, synthetic parylene substrate designed to mimic Bruch’s membrane.
AAV.sFH, is an investigational drug being developed by Aevitas Therapeutics. Aevitas advances AAV gene therapies of short-form human factor H (sFH) to restore homeostasis in disorders of complement dysregulation: dry age-related macular degeneration (Dry AMD), atypical hemolytic uremic syndrome (aHUS) and other disorders. sFH restored complement regulation in eyes of FH knockout mice with subretinal administration.
Supraphysiological expression of sFH with subretinal administration was shown in non-human primate eye. Good vector genome transfer to ocular target tissues with intravitreal administration was demonstrated in Yorkshire pigs. Transgene product sFH was present in all eye compartments with potentially clinically relevant FH levels in the porcine eye. Currently, the drug is in Preclinical stage of development for the treatment of Dry AMD.
Dry Age-Related Macular Degeneration Pipeline Therapeutics Assessment
There are approx. 55+ key companies which are developing the therapies for Dry Age-related Macular Degeneration. The companies which have their Dry Age-related Macular Degeneration drug candidates in the most advanced stage, i.e. Phase III include, Alkeus Pharmaceuticals.
Find out more about the Dry Age-Related Macular Degeneration Pipeline Segmentation, Therapeutics Assessment, and Dry Age-Related Macular Degeneration Emerging Drugs @ Dry Age-Related Macular Degeneration Treatment Landscape
Scope of the Dry Age-related Macular Degeneration Pipeline Report
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Table of Content
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